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  Indian J Med Microbiol
 

Figure 2 Histopathology of rat liver (H&E x250). (A) Control animals showing normal cytoarchitecture of the liver parenchyma. CV: central vein, H: Hepatocyte, S: sinusoid. (B) Negative control; 20 mL/kg ethanol was administered to animals in this group. The micrograph shows distorted cytoarchitecture as evidence by hepatocyte degeneration. HD: hepatocyte degeneration. (C) Liver of watermelon seed treated with 200 mg/kg body weight of the extract then ethanol. The photograph shows a relatively preserved cytoarchitecture. However, there was evidence of focal area showing degeneration of hepatocytes. Kupffer cells have become more numerous and conspicuous. H: hepatocyte, KC: Kupffer cell, FD: focal degeneration. (D) Liver of watermelon seed treated with 400 mg/kg body weight of the extract then ethanol. The micrograph showed an improved liver cytoarchitecture except for areas of focal degeneration of hepatocytes. S: sinusoid. (E) Liver of rats treated with standard drug silymarin then ethanol (positive control). The photograph shows normal histology and preserved liver cytoarchitecture as evidenced by the numerous viable hepatocyte and Kupffer cells.

Figure 2 Histopathology of rat liver (H&E x250). (A) Control animals showing normal cytoarchitecture of the liver parenchyma. CV: central vein, H: Hepatocyte, S: sinusoid. (B) Negative control; 20 mL/kg ethanol was administered to animals in this group. The micrograph shows distorted cytoarchitecture as evidence by hepatocyte degeneration. HD: hepatocyte degeneration. (C) Liver of watermelon seed treated with 200 mg/kg body weight of the extract then ethanol. The photograph shows a relatively preserved cytoarchitecture. However, there was evidence of focal area showing degeneration of hepatocytes. Kupffer cells have become more numerous and conspicuous. H: hepatocyte, KC: Kupffer cell, FD: focal degeneration. (D) Liver of watermelon seed treated with 400 mg/kg body weight of the extract then ethanol. The micrograph showed an improved liver cytoarchitecture except for areas of focal degeneration of hepatocytes. S: sinusoid. (E) Liver of rats treated with standard drug silymarin then ethanol (positive control). The photograph shows normal histology and preserved liver cytoarchitecture as evidenced by the numerous viable hepatocyte and Kupffer cells.