Sub-Saharan African Journal of Medicine

CASE REPORT
Year
: 2017  |  Volume : 4  |  Issue : 3  |  Page : 87--90

Probable lamivudine-resistant hepatitis B infection in children: A case report involving two Nigerian siblings at Ahmadu Bello University Teaching Hospital, Shika, Zaria


Sani M Mado, Hafsat W Idris, Sakinatu M Abdullahi, Sani Musa 
 Department of Paediatrics, ABU/ABUTH-Zaria, Zaria, Nigeria

Correspondence Address:
Sani M Mado
Department of Paediatrics, ABU/ABUTH-Zaria, Zaria
Nigeria

Currently, up to 65 million Africans have chronic hepatitis B (CHB) infection, with the majority acquiring it in the first 5 years of life and living in Nigeria. Lamivudine is generally accepted for use as the first-line treatment of CHB in children under the age of 12 years. However, the drug has a low genetic barrier to resistance. Lamivudine-resistant CHB is a serious challenge in resource-limited settings. This case report is intended to study a probable lamivudine-resistant CHB in two siblings aged 9 and 11 years and to highlight the challenges of managing CHB in children from resource-limited settings. There is a need to develop national guidelines for the management of CHB in children. Other suitable antiviral agents should be subsidized, so that they could be used to salvage lamivudine-resistant cases.


How to cite this article:
Mado SM, Idris HW, Abdullahi SM, Musa S. Probable lamivudine-resistant hepatitis B infection in children: A case report involving two Nigerian siblings at Ahmadu Bello University Teaching Hospital, Shika, Zaria.Sub-Saharan Afr J Med 2017;4:87-90


How to cite this URL:
Mado SM, Idris HW, Abdullahi SM, Musa S. Probable lamivudine-resistant hepatitis B infection in children: A case report involving two Nigerian siblings at Ahmadu Bello University Teaching Hospital, Shika, Zaria. Sub-Saharan Afr J Med [serial online] 2017 [cited 2024 Mar 29 ];4:87-90
Available from: https://www.ssajm.org/article.asp?issn=2384-5147;year=2017;volume=4;issue=3;spage=87;epage=90;aulast=Mado;type=0