ORIGINAL ARTICLE |
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Year : 2019 | Volume
: 6
| Issue : 2 | Page : 90-95 |
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Levels of interleukin 6 and 10 and their relationship to hematological changes in HIV treatment-naïve and treatment-experienced patients
Iorhen E Akase1, Reginald O Obiako2, Bolanle O. P Musa3, Adefolarin Opawoye1, Alani S Akanmu4
1 Infectious Disease Unit, Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria 2 Neurology Unit, Department of Medicine, Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Shika Zaria, Nigeria 3 Immunology Unit, Department of Medicine, Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Shika Zaria, Nigeria 4 Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria
Correspondence Address:
Iorhen E Akase Infectious Disease Unit, Department of Medicine, Lagos University Teaching Hospital, Lagos Nigeria
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/ssajm.ssajm_8_19
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Introduction: Human immunodeficiency virus (HIV) infection is characterized by excessive and dysregulated production of both proinflammatory and antiinflammatory interleukins, which produces various hematological changes. This study described hematological changes in HIV-positive patients in Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. Methods and Materials: This was a cross-sectional study involving 88 consecutive patients. They included 44 newly diagnosed antiretroviral treatment (ART)-naïve patients (as the test group), and 44 ART- experienced patients (as the control group). All 88 patients were evaluated for full blood count and CD4+ T-cell count as well as interleukins 6 and 10 assays. Results: The mean packed cell volume in the ART-naïve and the ART-experienced participants were 32.6 ± 5.7% and 38.6 ± 6.0% (P = 0.01). Mean hemoglobin were 10.8 ± 1.80 and 12.8 ± 1.66 g/dL in the ART-naïve and the ART-experienced participants (P = 0.01), whereas the mean corpuscular volume among the ART-naïve patients was 83.9 fL ± 7 and 99.3 fL ± 12 among the ART-experienced patients (P = 0.01). The median total white cell count among the ART-naïve and the ART-experienced patients were 5.6 × 109 and 3.1 × 109 (P = 0.04), whereas their total platelet counts were 227 × 109 ± 116 and 252 × 109 ± 95 (P = 0.29). Conclusion: Use of ART reduces inflammatory response to HIV, thus lowering levels of interleukins 6 and 10 ultimately improving hematological outcomes, except in a few patients who use zidovudine.
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