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Year : 2017  |  Volume : 4  |  Issue : 1  |  Page : 9-14

Evaluation of lipid profile in cord blood of full-term Nigerian newborn infants

1 Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
2 Department of Chemical Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria

Correspondence Address:
Lawal W Umar
Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Zaria
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DOI: 10.4103/ssajm.ssajm_44_16

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Background: Blood lipid profiles are known to be under the influence of genetic and environmental factors, with considerable age variation. While lipid levels are generally lower in childhood and may predict future risk for atherosclerosis, normal ranges in cord blood have not been fully evaluated in developing countries. Objective: To evaluate the cord blood lipid profiles for full-term newborn infants. Materials and Methods: A descriptive cross-sectional study was performed at Ahmadu Bello University Teaching Hospital, Zaria, involving 71 term newborn infants. At delivery, cord blood was collected and serum separated by centrifugation. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured using Selectra XL AutoAnalyser (HUMAN Gesellschaft für Biochemica und Diagnostica mbH, Wiesbaden, Germany), while the atherogenic index of plasma (AIP) was calculated from the lipid fractions. Using a standardised pro forma, obstetric and demographic data, and cord blood lipid levels were collected. Data were analysed using the Statistical Package for Social Sciences version 20.0 software (SPSS Inc., Chicago, Illinois, USA), and results were presented in tables and charts. A P value of <0.05 was considered as significant. Results: There were 38 males and 33 females. The mean TC, TG, HDL-C and LDL-C were 1.87 ± 0.10, 0.57 ± 0.05, 0.70 ± 0.04 and 1.02 ± 0.07 mmol/L, respectively. The mean TG concentration is lower while the LDL-C is higher than the standard reference values. The AIP was −0.09. Neither gender nor anthropometric differences were observed. Conclusion: This study has defined the cord blood lipid profile and reference ranges for full-term newborn infants, with no sex or anthropometric differences. Further studies are recommended to determine values for pre- and post-term infants.

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