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 Table of Contents  
ORIGINAL ARTICLE
Year : 2016  |  Volume : 3  |  Issue : 4  |  Page : 182-187

Pattern of urological cancers in Kano: North-western Nigeria


1 Urology Unit, Department of Surgery, Bayero University, Aminu Kano Teaching Hospital, Kano, Nigeria
2 Department of Pathology, Bayero University, Kano; Urology Unit, Department of Surgery, Bayero University, Aminu Kano Teaching Hospital, Kano, Nigeria
3 Department of Morbid Anatomy Forensic Medicine, Usmanu Danfodiyo University, Sokoto; Urology Unit, Department of Surgery, Bayero University, Aminu Kano Teaching Hospital, Kano, Nigeria

Date of Web Publication11-Jul-2017

Correspondence Address:
Abubakar Abdulkadir
Department of Surgery, Bayero University, Kano
Nigeria
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DOI: 10.4103/ssajm.ssajm_36_16

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  Abstract 

Background: The ubiquity of urological malignancies is evident in the epidemiological surveys despite the existing peculiarities in the pattern of their distribution among the different domains. There is, however, no publication on the foregoing for unified urological cancers from North-western Nigeria. This study, therefore, aimed to describe the spectrum, the frequency, the patient’s age and sex distributions of urological malignant tumours in Kano.
Materials and Methods: This was a 15-year retrospective review from 2nd January 2001 to 31st December 2015 of all the urological malignancies histologically diagnosed in Kano, Northern Nigeria. The analyzed variables included the patient’s age, sex, the organs involved and the histopathological category.
Results: Nine hundred and eight urological malignancies were diagnosed in the 15 year period under review; the male-to-female ratio was 16:1. Adult and paediatric patients added up to 880 (96.9%) and 28 (3.1%), respectively. The organs involved were the prostate (514; 56.6%), the bladder (327; 36.0%), the kidney (47; 5.2%), the testes (9; 1.0%), the penis (6; 0.7%), the urethra (4; 0.4%) and the ureter (1; 0.1%). The predominant prostate histological variant was adenocarcinoma (98.1%). Urothelial carcinomas constituted 48.0% of bladder cancers, whereas 55.3% of renal malignancies were nephroblastomas.
Conclusion: study unveiled high prevalence of urological cancers, particularly prostate and bladder cancers in the populace; consequently, the urge for greater commitment to a comprehensive urological cancer prevention and treatment plans.

Keywords: Bladder, kidney, prostate, urological cancers


How to cite this article:
Abdulkadir A, Alhaji SA, Sanusi HM. Pattern of urological cancers in Kano: North-western Nigeria. Sub-Saharan Afr J Med 2016;3:182-7

How to cite this URL:
Abdulkadir A, Alhaji SA, Sanusi HM. Pattern of urological cancers in Kano: North-western Nigeria. Sub-Saharan Afr J Med [serial online] 2016 [cited 2017 Nov 24];3:182-7. Available from: http://www.ssajm.org/text.asp?2016/3/4/182/210205


  Introduction Top


Urological cancers are the malignant tumours of the genitourinary and urinary system in male and female, respectively. The ubiquity of these tumours is evident in epidemiological studies, and they equal 14% global cancer prevalence.[1],[2] The pattern of urological cancer distribution, natural history and treatment outcome often varied with the era of the study likewise in between racial and socio-economic groups amid other different domains. These dissimilarities are inferred to be due to genetic proclivity and environmental determinants.[3],[4] As with many other cancers, ageing, hormonal factor, cigarette smoking, family history, obesity, hypertension, analgesic abuse, exposure to chemicals and heavy metals are the risk factors associated with increased prevalence.[5],[6],[7]

Urological cancers are common in Nigeria. A 10-year retrospective review of the cancer registry in Kano revealed prostate and bladder cancers as the first two most common in the male cancer profile, whereas bladder cancer was within the profile of 12 most common female cancers.[8] Urological cancers contribute a major share in cancer morbidities and mortalities, and it was projected that prevalence and cancer mortality will continue soaring, especially in the developing world, adding to the endemic infections and infestation as a major health problem.[9],[10]

There are several published studies on malignancies arising from distinctive organ components of the genitourinary system in North-western Nigeria.[11],[12],[13] There is, however, no unified study on urological cancers in Kano, North-western Nigeria. This study, therefore, aimed to analyze the frequency, the patient’s age, sex distribution and the morphological patterns of urological cancers in Kano, the largest city in Northern Nigeria.


  Materials and Methods Top


This was a 15-year retrospective review of a single subject’s histological entering on patients with urological cancers from 2nd January 2001 to 31st December 2015. The study was conducted in the only institution that provides histological diagnosis in Kano − Aminu Kano Teaching Hospital, Kano. The following variables were recorded: the patient’s age, sex, the organs involved and the histopathological variant of the malignancies.

Ethical clearance was obtained from the hospital ethics and scientific committee. Histological slides in all cases were retrieved and reviewed by the authors. Fresh sections were cut from archival paraffin blocks when slides could not be retrieved. All specimens had been previously fixed in 10% formal saline, ahead of the routine paraffin embedding. Microtome sections were 4 μm thick, and the prepared slides were stained with haematoxylin and eosin (H&E). Immunohistochemistry such as p63 was deployed where necessary. The diagnosis was based on the World Health Organization’s classification of varied urological cancers.[14]


  Results Top


Nine hundred and eight cases of urological malignancies were diagnosed during the 15-year study period, with a male-to-female ratio of 16:1. Adult and paediatric patients added up to 880 (96.9%) and 28 (3.1%), respectively. [Table 1] depicts the frequency distribution of urological malignancies and the peak age of presentation in the study population. The organs afflicted were the prostate (514; 56.6%), the bladder (327; 36.0%), the kidney (47; 5.2%), the testes (9; 1.0%), the penis (6; 0.7%), the urethra (4; 0.4%) and the ureter (1; 0.1%).
Table 1: Frequency distribution of urological malignancies and the peak age of presentation

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[Table 2] shows the histological types of urological malignancies in Kano. The overall age range of the patients with prostate cancers in this study was 36–95 years, and the peak incidence was seen in the 60–69 years age group; the majority of the prostate cancers were adenocarcinomas (98.1%). The age of the patients with bladder cancers ranged from 2 to 90 years, with the highest occurrence in the sixth decade of life and a male-to-female ratio of 7.6:1. Urothelial carcinomas constituted 48.0% of all the bladder cancers. Kidney cancers were 55.3% nephroblastomas in children that mostly occurred within the first decade of life and peaked in the 2–4 years age group, with a male-to-female ratio of 2:1. The renal cell carcinomas (RCCs) were, however, the most common in the sixth decade of life. Most of the testicular tumours occurred within the second to the fourth decade of life. The youngest patient was 3 years old, whereas the oldest was 49 years old, and germ cell tumours constituted 88.9%. The age range of the patients with penile cancers was from 50 to 75 years, and all the cases were squamous cell carcinomas (SCCs).
Table 2: Histological types of urological malignancies at the different site

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[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6] show photomicrographs of adenocarcinoma (H&E), adenocarcinoma (p63), urothelial carcinoma, well-differentiated SCC, RCC and nephroblastoma, respectively.
Figure 1: Adenocarcinoma of the prostate (H&E ×10)

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Figure 2: Adenocarcinoma of the prostate (p63 −ve ×10)

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Figure 3: Urothelial carcinoma of the urinary bladder (H&E ×10)

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Figure 4: Well-differentiated squamous cell carcinoma of the urinary bladder (H&E ×10)

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Figure 5: Renal cell carcinoma of the kidney (H&E ×10)

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Figure 6: Nephroblastoma of the kidney (H&E ×10)

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  Discussion Top


There were 908 cases of histologically confirmed urological malignancies, which represented 17.1% of all cancers diagnosed during the 15-year study period. This was comparable with other studies within the country, Europe and the USA.[15],[16],[17] Prostate cancer constituted 56.6% in this review, which is in keeping with its global dominance among urological malignancies.[15],[16],[17],[18] This also supported the earlier 10-year review from the same institution.[8] It, however, disputed the assertions that prostate cancer is relatively rare among indigenous Black Africans.[19] A high rate was observed among African-Americans in the USA, whereas the lowest rate was in China.[20],[21] This buttresses racial differences and environmental determinants as risk factors. The patients in our appraisal were predominantly in the 60–69 years age category. This parallel reports from other parts of Nigeria plus Cameroon and India. The Caucasians have 70–79 years as the dominating age group.[17],[18] Shorter life expectancy and unexplained environmental determinants could be the reasons for the variation. Most lesions are adenocarcinomas and comprised 98.1% which concurred with findings in the literature.[25],[26]

Bladder cancer is the next most common urological malignancy. The median age of the fifth decade of life in our study was found to be similar with the reports from Zambia, Egypt and Iraq.[27],[28],[29] The median age in England and Wales, however, was in the seventh decade of life but 65 years in the USA.[30],[31] This may be due to differences in life expectancy and high schistosomiasis prevalence in the developing world.[9],[10] In our study, the male-to-female ratio was 7.6:1, and hence, was less than 11.1:1 in Sokoto, but greater than 4:1 in Maiduguri, 2:1 in Jos and 2–3:1 in Ibadan.[32],[33],[34],[35],[36],[37] This male dominance was attested in other parts of the world; males are generally more prone to most of the risk factors. Initial appraisal in our setting showed SCC as the most common histological type.[38] However, in this review, transitional cell carcinoma and SCC were 48 and 44.6%, respectively, which was not far from the findings in Jos and Ibadan.[35],[39] This could be as a result of increasing awareness of the risks of untreated childhood haematuria from schistosomiasis in the study population.

Renal cancers were 5.2% of urological malignancies in our study, and it was 17.3% in Jos.[39] These were lower than in Caucasians.[40] Nephroblastoma comprised 55.3% of all renal cancers, with the peak age of 2nd to 4th year, which is comparable to those of other African series.[41],[42] RCC is usually seen in adults worldwide as revealed in our review. The age of 18–80 years in this study was similar to the worldwide age range.[43],[44],[45]

Testicular cancer accounted for 1.0% of urological malignancies in our review, and this concurred with reviews from other parts of African, the Caribbean and the Asian communities.[46],[47] The patient’s age range was from 3 to 49 years with a peak in the third decade of life. Germ cell tumours comprised 88.9%, and hence, this conformed to what was obtained in literature.[48],[49],[50] Likewise, penile cancer comprised 0.7% of all urological malignancies. This was close to the 1% reported in Jos and 0.4–0.6% in Europe and the USA. It is, however, lower than 4.4% in Swaziland and 2.9% in Rwanda.[39] The low prevalence in our population may not be detached from the tradition of circumcision in our populace cited as protective against penile cancer.[54] All cases were SCC, which was the main histological type reported in other series.[55],[56] Cancers of the urethra and ureter are distinctly rare.[57],[58]

Furthermore, the study affirmed a gradual overall increase in frequencies of urological malignancies particularly with bladder and prostate cancers [Figure 7]. This may be due to increased awareness of the risk factors, improved documentation, the introduction of prostate-specific antigen screening, newer needle biopsy techniques, improved imaging techniques and increasing cystoscopy among centres. However, increasing urbanization and changing lifestyle may have increased environmental risk and accounts for the rising prevalence.
Figure 7: Graph of frequency distribution of urological malignancies in Kano from 2001 to 2015

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This appraisal is not free from shortcomings of retrospective hospital-based reviews. Due to a significant number of patients presenting with an advanced stage tumor and strong societal disapproval of autopsy in our setting, a substantial number of yet to be biopsied cancer-specific mortalities are unaccounted for.[59] Likewise, not all the tissues get to our institution because of the vastness of the study domain and attached cost that histology incurred, however, considering its 17.1% of the malignant tumours histologically diagnosed in the institution implied high prevalence among malignancies.

In conclusion, urological cancers are common in Kano, Northern Nigeria. In this review, prostate and bladder cancers are the predominant group. Long-term prospective studies with long-term follow-up may add to our understanding of the epidemiology and prognostic makers. This will be an added pillar to comprehensive cancer prevention and treatment plans.

Acknowledgements

We are grateful to the Chief Laboratory Scientist of Aminu Kano Teaching Hospital and Mr. Sani Abubakar for his help in the laboratory technical work.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29.  Back to cited text no. 1
    
2.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:59-86.  Back to cited text no. 2
    
3.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.  Back to cited text no. 3
    
4.
Hsing AW, Tsao L, Devesa SS. International trends and patterns of prostate cancer incidence and mortality. Int J Cancer 2002;85:60-7.  Back to cited text no. 4
    
5.
Pienta KJ. Etiology, epidemiology and prevention of carcinoma of the prostate. In: Walsh PC, Retik AB, Vaughan ED, Wein AJ, editors. Campbell’s Urology. 7th ed. Philadelphia: Saunders; 1998. p. 2487-95.  Back to cited text no. 5
    
6.
Amonkar P, Murali G, Krishnamurthy J. Schistosoma induced squamous cell carcinoma of the bladder. Indian J Pathol Microbiol 2001;44:363-4.  Back to cited text no. 6
[PUBMED]  [Full text]  
7.
Setiawan VW, Stram DO, Nomura AM, Kolonel LN, Henderson BE. Risk factors for renal cell cancer: The multiethnic cohort. Am J Epidemiol 2007;166:932-40.  Back to cited text no. 7
    
8.
Mohammed AZ, Edino ST, Ochicha O, Gwarzo AK, Samaila AA. Cancer in Nigeria: A 10-year analysis of the Kano cancer registry. Niger J Med 2008;17:280-4.  Back to cited text no. 8
    
9.
Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data. Lancet 2006;367:1747-57.  Back to cited text no. 9
    
10.
Thomas JE, Bassett MT, Sigola L, Laylor P. Relationship between bladder cancer incidence, Schistosoma haematobium infection, and geographical region in Zimbabwe. Trans R Soc Trop Med Hyg 1990;84:551-3.  Back to cited text no. 10
    
11.
Alhaji SA, Abdulkadir A, Sanusi HM. A 15-year pathologic review of testicular and paratesticular tumours in Kano, Northern Nigeria. Niger J Basic Clin Sci 2016;13:114-8.  Back to cited text no. 11
  [Full text]  
12.
Isah RT, Sahabi SM, Adamu SN, Mohammed AT, Mungadi IA. Histopathological pattern of renal tumours seen in Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria. Afr J Cell Path 2013;1:9-13.  Back to cited text no. 12
    
13.
Oluwole OP, Rafindadi AH, Shehu MS, Samaila MO. A ten-year study of prostate cancer specimens at Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria. Afr J Urol 2015;21:15-8.  Back to cited text no. 13
    
14.
Eble JN, Sauter G, Epstein JI, Sesterhenn I. WHO Classification of Tumors. Pathology and Genetics. Tumours of the Urinary System and Male Genital System. Lyon: IARC Press; 2004. p. 10, 90, 160, 218, 280.  Back to cited text no. 14
    
15.
Ekwere PD, Egbe SN. The changing pattern of prostate cancer in Nigerians: Current status in the southeastern states. J Natl Med Assoc 2002;94:619-27.  Back to cited text no. 15
    
16.
Bono AV. The global state of prostate cancer: Epidemiology and screening in the second millennium. BJU Int 2004;94(Suppl 3):1-2.  Back to cited text no. 16
    
17.
McDavid K, Lee J, Fulton JP, Tonita J, Thompson TD. Prostate cancer incidence and mortality rates and trends in the United States and Canada. Public Health Rep 2004;119:174-86.  Back to cited text no. 17
    
18.
Ogunbiyi JO, Shittu OB. Increased incidence of prostate cancer in Nigerians. J Natl Med Assoc 1999;91:159-64.  Back to cited text no. 18
    
19.
Osegbe DN. Prostate cancer in Nigerians: Facts and nonfacts. J Urol 1997;157:1340-3.  Back to cited text no. 19
    
20.
Gueye SM, Zeigler-Johnson CM, Friebel T, Spangler E, Jalloh M, MacBride S et al. Clinical characteristics of prostate cancer in African Americans, American whites, and Senegalese men. Urology 2003;61:987-92.  Back to cited text no. 20
    
21.
Gromberg H. Prostate cancer epidemiology. Lancet 2003;361:859-64.  Back to cited text no. 21
    
22.
Odubanjo MO, Banjo AA, Ayoola S, Abdulkareem FB, Anunobi CC, Olayinka AA. The clinicopathologic pattern of prostatic carcinoma in Lagos, Nigeria. N Am J Med Sci 2013;6:71-5.  Back to cited text no. 22
    
23.
Ibrahim AG, Aliyu S, Dogo HM, Babayo UD, Zarami AB. Carcinoma of the prostate − A five year experience in Maiduguri north eastern Nigeria. Int J Appl Res 2015;1:512-4.  Back to cited text no. 23
    
24.
Angwafo FF. Migration and prostate cancer: An international perspective. J Natl Med Assoc 1998;90(11 Suppl):S720-3.  Back to cited text no. 24
    
25.
Sharma S, Nath P, Srivastava AN, Singh KM. Tumours of the male urogenital tract: A clinicopathologic study. J Indian Med Assoc 1994;92:357-60.  Back to cited text no. 25
    
26.
Crawford ED. Epidemiology of prostate cancer. Urology 2003;62:3-12.  Back to cited text no. 26
    
27.
Bowa K, Kachima JS, Labib MA, Mudenda V, Chilenya M. The pattern of urological cancers in Zambia. Afr J Urol 2009;15:15-9.  Back to cited text no. 27
    
28.
Felix AS, Soliman AS, Khaled H, Zaghloul MS, Banerjee M, El-Baradie M. The changing patterns of bladder cancer in Egypt over the past 26 years. Cancer Causes Control 2008;19:421-9.  Back to cited text no. 28
    
29.
Al-Nasri US. The changing pattern of bladder tumors, is there an environmental risk factor? Iraqi Postgrad Med J 2005;4:311-8.  Back to cited text no. 29
    
30.
Colombel M, Soloway M, Akaza H, Böhle A, Palou J, Buckley R et al. Epidemiology, staging, grading, and risk stratification of bladder cancer. Eur Urol Suppl 2008;7:618-26.  Back to cited text no. 30
    
31.
National Cancer Institute. Cancer Topics. Bladder Cancer. Available from: http://www.cancer.gov/. [Last accessed on2007 Apr].  Back to cited text no. 31
    
32.
Mungadi IA, Malami SA. Urinary bladder cancer and schistosomiasis in North-western Nigeria. West Afr J Med 2007;26:226-9.  Back to cited text no. 32
    
33.
Eni UE, Na’aya HU, Nggada HA, Dogo D. Carcinoma of the urinary bladder in Maiduguri: The schistosomiasis connection. Internet J Oncol 2007;5:1.  Back to cited text no. 33
    
34.
Mandong BM. Carcinoma of the urinay bladder in Jos, Nigeria. Niger Med Pract 1997;33:33-4.  Back to cited text no. 34
    
35.
Thomas JO, Onyemenen NT. Bladder carcinoma in Ibadan Nigeria: A changing trend? East Afr Med J 1995;72:49-50.  Back to cited text no. 35
    
36.
Zaghloul MS, Nouh A, Moneer M, El-Baradie M, Nazmy M, Younis A. Time-trend in epidemiological and pathological features of schistosoma-associated bladder cancer. J Egypt Natl Canc Inst 2008;20:168-74.  Back to cited text no. 36
    
37.
Atallah A, Shaaban MD, Saad A, Orkubi AF, Mohammed T, Yousef B et al. Squamous cell carcinoma of the urinary bladder. Ann Saudi Med 1997;17:115-9.  Back to cited text no. 37
    
38.
Ochicha O, Alhassan S, Mohammed AZ, Edino ST, Nwokedi EE. Bladder cancer in Kano. A histopathological review. West Afr J Med 2003;22:202-4.  Back to cited text no. 38
    
39.
Mandong BM, Iya D, Obekpa PO, Orkar KS. Urological tumours in Jos University Teaching Hospital, Jos, Nigeria. Niger J Surg Res 2000;2:108-13.  Back to cited text no. 39
    
40.
Kirkali Z, Cal C. Renal cell carcinoma: Overview. In: Nargund VH, Raghavan D, Sandler HM, editors. Urological Oncology. London: Springer; 2008.p. 263-80.  Back to cited text no. 40
    
41.
Sow M, Nkegoum B, Oyono JL, Garoua XX, Nzokou A. Epidemiological and histological features of urogenital tumours in Cameroon. Prog Urol 2006;16:36-9.  Back to cited text no. 41
    
42.
Klufio GO. A review of genitourinary cancers at the Korle-Bu teaching hospital Accra, Ghana. West Afr J Med 2004;23:131-4.  Back to cited text no. 42
    
43.
Aghaji AE, Odoemene CA. Renal cell carcinoma in Enugu, Nigeria.West Afr Med J 2000;19:254-8.  Back to cited text no. 43
    
44.
Dauda MM, Misauno MA, Ojo EO, Nnadozie UU, Ngba JA. A review of urologic malignancies seen at Federal Medical Centre, Gombe northeastern Nigeria. Niger J Med 2012;21:237-40.  Back to cited text no. 44
    
45.
Yip SK, Cheng WS, Tan BS, Li MK, Foo KT. Partial nephrectomy for renal tumours: The Singapore General Hospital experience. J R Coll Surg Edinb 1999;44:156-60.  Back to cited text no. 45
    
46.
Forman D, Moller H. Trends in incidence and mortality of testicular cancer. Cancer Surv 1994;19-20: 323-41.  Back to cited text no. 46
    
47.
Garner MJ, Turner MC, Ghadirian P, Krewski D. Epidemiology of testicular cancer: An overview. Int J Cancer 2005;116:331-9.  Back to cited text no. 47
    
48.
Coleman MP, Estève J, Damiecki P, Arslan A, Renard H. Trends in cancer incidence and mortality. IARC Sci Publ 1992;121:1-806.  Back to cited text no. 48
    
49.
Deore KS, Patel MB, Gohil RP, Delvadiya KN, Goswami HM. Histopathological analysis of testicular tumours: A 4-year experience. Int J Med Sci Public Health 2015;4:554-7.  Back to cited text no. 49
    
50.
Haughey BP, Graham S, Brasure J, Zielezny M, Sufrin G, Burnett WS. The epidemiology of testicular cancer in upstate New York. Am J Epidemiol 1989;130:25-36.  Back to cited text no. 50
    
51.
Bleeker MC, Heideman DA, Snijders PJ, Horenblas S, Dillner J, Meijer CJ. Penile cancer: Epidemiology, pathogenesis and prevention. World J Urol 2009;27:141-50.  Back to cited text no. 51
    
52.
Chaux A, Cubilla AL. Advances in the pathology of penile carcinomas. Hum Pathol 2012;43:771-89.  Back to cited text no. 52
    
53.
Parkin DM, Ferlay J, Hamdi-Cherif M, Sitas F, Thomas JO, Wabinga H et al. Cancer Incidence in Africa. Lyon: International Agency for Research on Cancer 2003.  Back to cited text no. 53
    
54.
Schoen EJ, Oehrli M, Colby CD, Machin G. The highly protective effect of newborn circumcision against invasive penile cancer. Pediatrics 2000;105:E36.  Back to cited text no. 54
    
55.
Ajekigbe AT, Anunobi CC, Tijani KH, Banjo AA, Nweke IG. Carcinoma of the penis: Experience from the Lagos University Teaching Hospital Lagos, Nigeria. Niger Q J Hosp Med 2011;21:25-8.  Back to cited text no. 55
    
56.
Koifman L, Vides AJ, Koifman N, Carvalho JP, Ornellas AA. Epidemiological aspects of penile cancer in Rio de Janeiro: Evaluation of 230 cases. Int Braz J Urol 2011;37:231-40.  Back to cited text no. 56
    
57.
Aghaji AE, Onoyona AU. Urethral cancers in Enugu, Nigeria. Lagos J Surg 1999;2:15-19.  Back to cited text no. 57
    
58.
Aghaji AE, Mbonu OO. Cancer of the ureter in a negro population. J R Coll Surg Edinb 1991;36:306-8.  Back to cited text no. 58
    
59.
Dawan D, Rafindadi AH, Kalayi GD. Benign prostatic hyperplasia and prostate carcinoma in native Africans. BJU Int 2000;85:1074-7.  Back to cited text no. 59
    


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  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7]
 
 
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