|Year : 2015 | Volume
| Issue : 2 | Page : 64-69
Prevalence and Risk Factors for Perinatal Asphyxia as Seen at a Specialist Hospital in Gusau, Nigeria
Bilkisu Garba Ilah1, Muhammad Sakajiki Aminu2, Abdullahi Musa3, Muyideen Bimbo Adelakun1, Akeem Oladiran Adeniji1, Taofik Kolawole1
1 Departments of Paediatrics, Yariman Bakura Specialist Hospital, Gusau, Zamfara State, Nigeria
2 Department of Medicine, Yariman Bakura Specialist Hospital, Gusau, Zamfara State, Nigeria
3 Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria
|Date of Submission||11-Aug-2014|
|Date of Acceptance||18-Feb-2015|
|Date of Web Publication||20-May-2015|
Dr. Bilkisu Garba Ilah
Department of Paediatrics, Yariman Bakura Specialist Hospital, Gusau, PMB 1010, Gusau, Zamfara State
Introduction: Perinatal asphyxia is a global neonatal problem which significantly contributes to both morbidity and mortality. It is the fifth largest cause of under-five mortality. This study was aimed to determine the prevalence, risk factors and outcome of perinatal asphyxia in newborns seen in the Special Care Baby Unit. Materials and Methods: A retrospective study of newborns managed for perinatal asphyxia over a 1-year period. All inborn babies with Apgar scores <6 at 5 min and out born babies with no Apgar score but with features of asphyxia were studied. Case files of the patients were retrieved and relevant information was obtained. Results: Of the 223 neonates admitted during the study period, 67 (30.1%) newborns had perinatal asphyxia from our record; but only 47 (70.1%) case files with complete data were retrieved, giving a prevalence of 21.1%. Twenty five (53.2%) of the mothers were primiparous, 31 (66.0%) had no antenatal care and 25 (53.2%) presented with prolonged obstructed labor. Twenty-eight (59.6%) of the newborns were females; 41 (87.2%) were term, 27 (57.4%) of normal birth weight, 42 (89.4%) delivered in the hospital and mostly through an emergency caesarean section. Thirty (63.9%) of the newborns were discharged; while 12 newborns died, giving a case fatality rate of 25.5%. Conclusion: Perinatal asphyxia is a significant cause of morbidity and mortality in Gusau. Health education of pregnant mothers on antenatal care for early detection of high-risk pregnancy is highly recommended in order to reduce the high incidence of this preventable condition.
Keywords: Apgar, asphyxia, newborn, perinatal
|How to cite this article:|
Ilah BG, Aminu MS, Musa A, Adelakun MB, Adeniji AO, Kolawole T. Prevalence and Risk Factors for Perinatal Asphyxia as Seen at a Specialist Hospital in Gusau, Nigeria. Sub-Saharan Afr J Med 2015;2:64-9
|How to cite this URL:|
Ilah BG, Aminu MS, Musa A, Adelakun MB, Adeniji AO, Kolawole T. Prevalence and Risk Factors for Perinatal Asphyxia as Seen at a Specialist Hospital in Gusau, Nigeria. Sub-Saharan Afr J Med [serial online] 2015 [cited 2019 Oct 20];2:64-9. Available from: http://www.ssajm.org/text.asp?2015/2/2/64/157421
| Introduction|| |
Perinatal asphyxia is a common and serious neonatal problem globally and it significantly contributes to both neonatal morbidity and mortality. According to the World Health Organization (WHO) in 2000, of the 130 million infants born globally each year, approximately 4 million babies die before they reach the age of 1-month.  It has been shown that 99% of these neonatal deaths take place in the developing countries where perinatal asphyxia contributes to almost 23% of these deaths.  Over half of these deliveries occur at home.  In the latest World Health Statistics 2013,  neonatal deaths have decreased from 4.4 million in 1990 to 3 million in 2011.
Perinatal asphyxia is estimated to be the fifth largest cause of under-five child deaths (8.5%), after pneumonia, diarrhea, neonatal infections and complications of preterm birth.  Millennium developmental goal 4 (aiming at a two-thirds reduction in under-five mortality by the year 2015 from a baseline in 1990) can only be met by substantially reducing neonatal deaths. Indeed, newborn deaths constitute over 40% of all deaths in children aged under five. 
Asphyxia is defined as the inability of the newborn to initiate and sustain adequate respiration after delivery.  The American College of Obstetricians and Gynecologists and the American Academy of Pediatrics assign a neonate to be asphyxiated if the following conditions are fulfilled: Umbilical cord arterial pH <7; Apgar score of 0-3 for longer than 5 min; neurological manifestations (e.g., seizures, coma, or hypotonia); and multisystem organ dysfunction, e.g., cardiovascular, gastrointestinal, hematological, pulmonary or renal system. 
Having gone through the literature, there is no documented report on perinatal asphyxia from this area despite its high contribution to neonatal morbidity and mortality. This study was carried out to determine the prevalence of perinatal asphyxia in our Special Care Baby Unit (SCBU). We also aimed to determine the risk factors, mode of delivery and outcome of newborns admitted with perinatal asphyxia.
| Materials and Methods|| |
This study was conducted in the SCBU of Yariman Bakura Specialist Hospital (YBSH) Gusau. The hospital is the specialist hospital of the Zamfara State Government, Nigeria. It serves as a secondary and Tertiary Care Centre for the state capital, as well as a referral center for all the local government areas of the state. This is a descriptive retrospective cross- sectional study of newborns admitted and managed for perinatal asphyxia between 1 st April 2013 and 31 st March 2014 in YBSH.
All inborn babies with Apgar scores <6 at the 5 th min of life and out born babies with no Apgar score, but with a history of poor cry or inability to cry from birth, with poor color, respiratory distress, floppiness  or multi organ involvement were reviewed. Late preterm (near term), term, and post term babies were included in the study.
Apgar score was one of the criteria used to define birth asphyxia in this study, due to unavailability of blood gas analysis in babies delivered in the hospital. It is moderate asphyxia if the 5 min Apgar score is 4-5, or required stimulation and oxygen administration before a cry. Severe asphyxia is when the score is 0-3 or is associated with seizures, central cyanosis or coma; or history of inability to cry in those without Apgar score.  Newborns with low Apgar score or history of inability to cry with organ involvement such as renal or cardiac were also included.
Exclusion criteria include neonates suffering from major congenital anomalies or syndromes and preterm babies <35 completed weeks because the Apgar scores of non-asphyxiated preterm babies are normally low due to poor neurological maturity. Birth weights were divided into low birth weight (<2500 g), normal birth weight (2500 g to <4000 g) and macrosomia (>4000 g).
Case files of the patients were retrieved and relevant information were obtained which include: Age, sex, birth weight, gestational age, parity of mothers, booking status, mode of delivery, Apgar score for inborn, place of delivery, and problems during pregnancy or labor in the mothers.
Data were entered into SPSS version 16 (SPSS Inc., Chicago, IL, USA), for cleaning and analysis using standard methods. Quantitative variables were summarized using mean and standard deviation. Categorical variables were summarized using frequency and percentages. Chi-square test and Fisher's exact test (for sample size <5 in a cell) were used for association between categorical variables. A P < 0.05 was considered statistically significant.
| Results|| |
During the study period, a total of 223 neonates were admitted into the SCBU, of which 67 (30.1%) babies were managed as cases of perinatal asphyxia as documented in our record book. However; we were able to retrieve case files of 47 (70.1%) babies that had complete data, which gave us a prevalence of 21.1%. There were 19 (40.4%) males and 28 (59.6%) females; giving a male:female ratio of 0.68:1.
Highest number of cases was seen in the month of June, and no case was admitted in December as shown in [Figure 1].
A total of 37 (78.7%) babies presented <12 h of life, 8 (17.0%) between 12 and 24 h and only 2 (4.3%) presented after 24 h of life.
Most of the mothers of the newborns with asphyxia were primiparous, unbooked and presented with prolonged obstructed labor as shown in [Table 1]. The most common co morbid condition in the mothers was the eclampsia.
Majority of the newborns were term, of normal birth weight and delivered in the hospital mostly through an emergency caesarean section as shown in [Table 2]. The mean birth weight was 3.60 ± 0.58 kg.
Six (12.8%) of the newborns presented with seizures, 5 (10.6%) with inability to suck and 42 (89.4%) with inability to cry after birth and all of them were hypotonic. Fourteen (29.8%) had Apgar score of 0-3 while 28 (59.6%) had Apgar score of 4-5. Five (10.6%) had no Apgar score as they were delivered at home.
The average duration of hospital stay was 3.8 ± 4.12 days, with a minimum of 1 h and a maximum of 18 day; with 38 (80.9%) neonates staying for a period of 7 days. Thirty (63.9%) of the newborns were discharged, 5 (10.6%) left against medical advice and 12 died resulting in a case fatality rate of 25.5%.
The risk factors for asphyxia were hospital delivery, delivery through caesarean section and eclamptic mother as shown in [Table 3]. Even though most of the mothers were unbooked, had prolonged obstructed labor and were primiparous, with the majority of the newborns being term, these were not significantly associated with Apgar score as shown in [Table 3].
Overall neonatal mortality from perinatal asphyxia over the study period was 5.4%. Five (41.7%) newborns died following delivery through emergency caesarean section while the remaining seven (58.3%) that died were delivered through spontaneous vaginal delivery. Nine (75%) newborns from mothers that had prolonged obstructed labor died while the remaining three (25%) survived. Nine (64.3%) out of the 14 babies with Apgar score of <3 died. Mortality was significantly associated with low Apgar score (Fisher's exact = 0.000). However, it was not associated with mode of delivery (χ2 = 2.146, P = 0.143), place of delivery (Fisher's exact = 1.000) nor with prolonged obstructed labor (Fisher's exact = 0.103). Booking status did not affect mortality statistically (χ2 = 0.417, P = 0.518). There was no association between mortality and gender, even though, more females than males died from asphyxia (χ2 = 0.010, P = 0.919).
| Discussion|| |
The overall prevalence rate of perinatal asphyxia was 21.1%. This high rate could be explained by the fact that our hospital is the state referral center where complicated cases are referred. Previous studies on perinatal asphyxia provided separate prevalence rates for categories of asphyxia. ,,
Our prevalence rate for severe birth asphyxia is higher than what has been obtained by West et al.  in Port Harcourt, Mukhtar-Yola and Iliyasu  in Kano, Okechukwu et al.  in Abuja, Nayeri et al.  in Tehran and Kinoti  in east, central and southern Africa. However, this was lower than what Ugwu et al.  obtained in Warri.
The prevalence rate obtained for moderate birth asphyxia is lower than what was obtained by West et al.  in Port Harcourt, but higher than what Mukhtar-Yola and Iliyasu  in Kano and Ugwu et al.  in Warri obtained. Omoigberale et al.  in a 4 year review found asphyxia to be a significant cause of morbidity in Benin. Low Apgar score, especially at 5 min was universally accepted to predict survival.  However, its inability to correctly diagnose perinatal asphyxia and predict long-term neurodevelopmental disabilities attracted criticism. 
Various criteria used in defining perinatal asphyxia could be responsible for the differences in prevalence rates. First, varied incidence observed in various studies could be due to various definitions of perinatal asphyxia used by the authors of the studies cited in the present study. Second, this study was conducted in the State Tertiary Centre where many of the high-risk pregnancies are referred and managed. Thirdly, most of the mothers' presented late and there was also delay in obtaining consent for caesarean section by the mother and or her husband, hoping that she may eventually deliver spontaneously. Fourth, different studies were carried out over different periods. These reasons could justify the higher incidence of birth asphyxia and poorer outcome in the different studies.
In this study, more females were found to have suffered from asphyxia which contrasts to what has been found in Port Harcourt,  Warri,  Iran,  Johannesburg  and India.  The reason for this difference could be due to higher birth rate of females during the study period.
Most of the babies were term; which is in agreement with previous reports by Onyearugha,  Etuk et al.,  and Uzoigwe et al.  The reason for this may be due to the fact that mature and larger newborns are more likely to be associated with feto-pelvic disproportion, which results in prolonged or obstructed labor and birth asphyxia as compared with low birth weight babies. 
Our study has also shown that asphyxia is more common in babies of unbooked mothers as seen in Warri,  India,  and Port Harcourt  unlike what was reported in Port Harcourt  and Johannesburg  where most of the mothers were booked. This leads to late diagnosis of high risk pregnancies; poor obstetrics outcome and risk of perinatal asphyxia.
Prolonged obstructed labor was not found to be a common risk factor of asphyxia in our study, similar to what was found by Dalal et al.  in India. This contrasts reports by Ugwu et al.,  Kinoti,  Onyearugha et al.  and Oswyn et al.  Reason for this cannot be explained even though 53.2% of the mothers had prolonged labor as some families in Gusau present late to the hospital for delivery when the mother is unable to deliver by herself or when complications occur.
Eclampsia was a found to be a risk factor of asphyxia in our study unlike what was found in India.  We found that pregnancy-induced hypertension was uncommon, unlike in Benin  and Indian  studies. Reason for these may be attributed to some mothers not attending antenatal clinics in the northern part of the country; as a result those with pregnancy induced hypertension are not treated early and they end up presenting with eclampsia.
Parity of mothers was not found to be associated with mortality unlike what was reported by Onyiriuka  in Benin. However, our study highlighted primiparity to be common even though not a significant risk factor of asphyxia in our study as they constituted a large percentage of the mothers similar to what was reported by Kinoti,  Dalal et al.  and Onyearugha et al.  It has been shown that, primiparous women are often ignorant of the demands of pregnancy there by neglecting early booking and regular attendance to antenatal care.  This may result in complications of prolonged labor, which may subsequently end up with delivery of asphyxiated babies.
Hospital delivery was found to be associated with asphyxia in our study, similar to what was found in Port Harcourt by West et al.  This may be explained by the fact that our hospital is a referral center where cases that could not be managed by other hospitals are referred to and also where women with pregnancy/labor complications attend without referral. These could lead to fetal complications with resultant fetal distress and eventually perinatal asphyxia.
Place of delivery was not associated with mortality in our study, even though most mothers delivered in the hospital; this was in disagreement with what was reported by Padayachee et al.  in Johannesburg study. The reason for this cannot be explained, as it is expected that babies delivered at home should have a higher mortality since intervention is not offered immediately at home.
Mode of delivery in our study was found to be a risk factor for asphyxia as most of the women came with complications requiring immediate intervention. Delivery was mostly by emergency caesarean section, similar to what was reported in Iran  and Port Harcourt.  This could be explained by the fact that indications for the caesarean sections were mostly due to prolonged obstructed labor or eclampsia. This is unlike what was observed in Hyderabad  and Johannesburg,  where most of the newborns were delivered by vaginal route; although newborns delivered through caesarean section were mostly due to emergencies and some due to obstructed labor.
Birth weight of the babies was consistent with what was reported in Port Harcourt  and Johannesburg.  Most of our patients presented within the 1 st 12 h, and by 24 h 95.7% had presented to the hospital. This was higher than 81.0% and 71.6% observed in India by Memon et al.  and Sehgal et al.  The difference may be due to the fact that Sehgal et al.  included all neonatal admissions while our study was only on asphyxiated babies who needed earlier admission for resuscitation or whose parents feared other serious complications and presented earlier.
Seizures which are seen in babies with severe asphyxia, were seen in 12.8% of the newborns which was in consonance with the report from Benin;  but lower than what was reported in Johannesburg.  Aire de  reported seizures to be common in asphyxiated babies in Jos.
Duration of hospital stay was similar to Port Harcourt  and Johannesburg  studies. Reason for such similarity cannot be explained.
Our case fatality rate from perinatal asphyxia was unacceptably high as a quarter of the asphyxiated newborns died. This may be explained by the fact that most of the mothers were un-booked, presented with prolonged obstructed labor and some of them had pregnancy complications such as eclampsia and pre eclampsia. The case fatality rate is similar to reports from Abuja,  Warri,  India  and Benin.  Mortality from asphyxia was also found to be high in Ilesha  and Sagamu.  Furthermore, our fatality rate is higher than what was reported in Johannesburg  and India.  However, it was lower than what has been reported in Papua New Guinea.  Although we have reported high case fatality rate, asphyxia contributed to a low overall neonatal mortality rate, lower than what has been reported in many studies.
Pregnancy and labor complications that contributed to asphyxia in our study may have resulted from inadequate antenatal care and supervision of labor in the mothers. This highlights the need for antenatal care with regular visits and for delivery in health facilities.
| Conclusion|| |
This study has shown perinatal asphyxia to be a significant cause of morbidity and mortality in neonates seen at YBSH, Gusau. It was more common in babies of un-booked primiparous women who presented with eclampsia, prolonged obstructed labor and delivered through emergency caesarean section. Health education of pregnant mothers on the need to attend antenatal care for early detection of high-risk pregnancy is highly recommended in order to reduce the high incidence of this preventable condition.
| Limitation|| |
In this study, we used Apgar score and clinical signs to diagnose asphyxia. Our Apgar scores are believed to be assigned correctly by the maternity staff, obstetricians and pediatric doctors present at deliveries. However, using Apgar score alone to diagnose perinatal asphyxia has been found to be unreliable especially in predicting the outcome. 
| References|| |
Lawn JE, Cousens S, Zupan J, Lancet Neonatal Survival Steering Team. 4 million neonatal deaths: When? Where? Why? Lancet 2005;365:891-900.
Bryce J, Boschi-Pinto C, Shibuya K, Black RE, WHO Child Health Epidemiology Reference Group. WHO estimates of the causes of death in children. Lancet 2005;365:1147-52.
Ezechukwu CC, Ugochukwu EF, Egbuonu I, Chukwuka JO. Risk factors for neonatal mortality in a regional tertiary hospital in Nigeria. Niger J Clin Pract 2004;7:50-5.
Azra Haider B, Bhutta ZA. Birth asphyxia in developing countries: Current status and public health implications. Curr Probl Pediatr Adolesc Health Care 2006;36:178-88.
Stoll JB, Kliegman RM. The fetus and the neonatal infant. In: Berhman RE, Kliegman RM, Jenson HB, editors. Nelson Textbook of Paed. 16 th
ed. Philadelphia: WB Saunders Company; 2000. p. 454-9.
Olowu JA, Azubuike JC. Assessment and care of the newborn infant. In: Azubuike JC, Nkanginime KEO, editors. Paediatrics and Child Health in a Tropical Region. Owerri, Nigeria: African Educational Series; 1999. p. 38-43.
West BA, Opara PI. Perinatal asphyxia in a specialist hospital in Port Harcourt, Nigeria. Niger J Paediatr 2013;40:206-10.
Mukhtar-Yola M, Iliyasu Z. A review of neonatal morbidity and mortality in Aminu Kano Teaching Hospital, northern Nigeria. Trop Doct 2007;37:130-2.
Ugwu GI, Abedi HO, Ugwu EN. Incidence of birth asphyxia as seen in central hospital and GN children′s clinic both in Warri Niger Delta of Nigeria: An eight year retrospective review. Glob J Health Sci 2012;4:140-6.
Okechukwu AA, Achonwa A. Morbidity and mortality patterns of admissions into the Special Care Baby Unit of University of Abuja Teaching Hospital, Gwagwalada, Nigeria. Niger J Clin Pract 2009;12:389-94.
Nayeri F, Shariat M, Dalili H, Bani Adam L, Zareh Mehrjerdi F, Shakeri A. Perinatal risk factors for neonatal asphyxia in Vali-e-Asr hospital, Tehran-Iran. Iran J Reprod Med 2012;10:137-40.
Kinoti SN. Asphyxia of the newborn in east, central and southern Africa. East Afr Med J 1993;70:422-33.
Omoigberale AI, Sadoh WE, Nwaneri DU. A 4 year review of neonatal outcome at the University of Benin Teaching Hospital, Benin City. Niger J Clin Pract 2010;13:321-5.
Casey BM, McIntire DD, Leveno KJ. The continuing value of the Apgar score for the assessment of newborn infants. N Engl J Med 2001;344:467-71.
Papile LA. The Apgar score in the 21st century. N Engl J Med 2001;344:519-20.
Padayachee N, Ballot DE. Outcomes of neonates with perinatal asphyxia at a tertiary academic hospital in Johannesburg, South Africa. SAJCH 2013;7:89-94.
Dalal CA, Bodar NL. Astudy on birth asphyxia at tertiary health centre. Natl J Med Res 2013;3:374-6.
Etuk SJ, Etuk IS, Ekott MI, Udoma EJ. Perinatal outcome in pregnancies booked for antenatal care but delivered outside health facilities in Calabar, Nigeria. Acta Trop 2000 25;75:29-33.
Uzoigwe SA, John CT. Maternal mortality in the University of Port Harcourt Teaching Hospital, Port Harcourt in the last year before the new millennium. Niger J Med 2004;13:32-5.
Onyearugha CN, Ugboma HA. Severe birth asphyxia: Risk factors as seen in a tertiary institution in the Niger Delta area of Nigeria. Control J Trop Med 2010;4:11-9.
Oswyn G, Vince JD, Friesen H. Perinatal asphyxia at Port Moresby General Hospital: A study of incidence, risk factors and outcome. P N G Med J 2000;43:110-20.
Onyiruika AN. Birth asphyxia in a Nigerian mission hospital in Benin city. Trop J Obstet Gynaecol 2006;23:34-9.
Memon S, Shaikh S, Bibi S. To compare the outcome (early) of neonates with birth asphyxia in-relation to place of delivery and age at time of admission. J Pak Med Assoc 2012; 62:1277-81.
Sehgal A1, Roy MS, Dubey NK, Jyothi MC. Factors contributing to outcome in newborns delivered out of hospital and referred to a teaching institution. Indian Pediatr 2001;38:1289-94.
Airede AI. Birth asphyxia and hypoxic-ischaemic encephalopathy: Incidence and severity. Ann Trop Paediatr 1991;11:331-5.
Ogunlesi TA, Oseni SB. Severe birth asphyxia in Wesley Guild Hospital, Ilesa; a persistent plague. Niger Med Pract 2008;53:40-3.
Njokanma OF, Olanrewaju DM. A study of neonatal deaths at the Ogun State University Teaching Hospital, Sagamu, Nigeria. J Trop Med Hyg 1995;98:155-60.
Leuthner SR, Das UG. Low Apgar scores and the definition of birth asphyxia. Pediatr Clin North Am 2004;51:737-45.
[Table 1], [Table 2], [Table 3]
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